What Not to Mix with Niacinamide?

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The beauty industry has been booming as of late. Women (and men) are becoming more and more interested in taking care of their skin and looking their best. This has led to the rise of many new skincare products and ingredients like niacinamide. Due to its many benefits, niacinamide has become a popular skincare ingredient, and today, many skincare products contain this ingredient. But since skincare routines can be a bit overwhelming and confusing, users are left with the question- what not to mix with niacinamide?

What is Niacinamide and What Does It Do?

Niacinamide is a form of vitamin B3. It is an antioxidant that is important for cell repair. Niacinamide is a precursor to two co-enzymes within your cells: NAD and NADP. It has many benefits for the skin. It can help to:

  • Reduce the appearance of fine lines and wrinkles.
  • Brighten skin tone.
  • Reduce the appearance of enlarged pores.
  • Improve uneven skin texture.
  • Reduce inflammation.
  • Stimulate collagen production.
  • Soften fine lines and wrinkles.
  • Strengthen skin barrier.

What Not to Mix with Niacinamide?

Niacinamide cannot be mixed with acidic skincare ingredients, such as AHAs and BHAs. Why? Acids have a pH between 3 and 4, while niacinamide has a pH between 5 and 7.5. When mixed with AHAs or BHAs, niacinamide raises the acid’s pH, making it less effective and harder for the skin to absorb. This combination may also produce flushing and redness.

Vitamin C is another compound that cannot be combined with niacinamide. The latter can cancel out vitamin C’s beneficial effects by turning it into a chemical that promotes redness, irritation, and acne outbreaks.

So, it is best to leave at least 20-30 minutes between using Niacinamide and any other acidic skincare ingredients. Another option is to use Niacinamide in your morning skincare routine and use the acidic ingredients that can make skin photosensitive at night. This way, you will avoid any adverse reactions to these ingredients.

What Can You Mix With Niacinamide?

Niacinamide can be mixed with most skincare products, but some go well with it. One of them is retinol, a form of vitamin A. Retinol is known for being very potent and can cause side effects like dryness, flakiness, and irritation. However, when you mix it with niacinamide, you can help reduce the irritation while still enjoying the benefits of retinol. This can help you achieve quicker and more effective results with fewer side effects.

Adding a moisturizer or serum containing niacinamide to your retinol routine can help keep your skin barrier healthy and hydrated. This allows the retinol to work its magic without causing as much irritation. In the long run, this can help reduce the appearance of fine lines and wrinkles.

Niacinamide works well with many other skincare products, including those containing peptides, hyaluronic acid, and similar ingredients.

What Should I Put On My Face After Niacinamide?

If you are using it in the morning, you should follow it with sunscreen. This is because niacinamide can make your skin more sensitive to the sun. If you are using it at night, you can follow it with any other product in your routine.

Is Niacinamide Scientifically Proven?

Yes, it is scientifically proven to be effective for several skin concerns. Studies have shown that Niacinamide can help to reduce hyperpigmentation, increase skin lightness, and improve collagen synthesis.

One of the most comprehensive studies on niacinamide was conducted in 2010 by J Levin. The study found that Niacinamide is potentially an antioxidant that can decrease skin hyperpigmentation, improve epidermal barrier function, increase skin lightness, and inhibit melanosome transfer.

Another study done in 2002 by Donald L. Bissett found that Niacinamide (4%) has anti-inflammatory and antioxidant properties ideal for improving skin hydration and skin barrier, which can help reduce tissue stress associated with poor barrier.

The studies mentioned above are just a few of the many studies that have been conducted on niacinamide and its efficacy. If you are interested in trying Niacinamide, be sure to look for products that contain high concentrations of Niacinamide (5% or higher). Niacinamide is a safe ingredient for all skin types and can be used daily.

Do Dermatologists Recommend Niacinamide?

Yes. Niacinamide has won over the hearts of dermatologists for its ability to improve a wide variety of skin concerns. According to Annie Gonzalez, MD, dermatologists recommend niacinamide because it can help improve several different skin conditions.

It can help repair the damage done to the skin’s barrier by exposure to sunlight and pollution. Additionally, it can help to reduce inflammation and irritation of the skin. Therefore, it may be a helpful tool for those looking to improve their skin’s overall health.


What Not to Mix with Niacinamide?

Can you mix niacinamide and hyaluronic acid?

Yes! Niacinamide can be mixed with hyaluronic acid since they are both water-based ingredients. This combination can help to improve the appearance of fine lines and wrinkles while also providing your skin with a boost of hydration.

Can I mix niacinamide with salicylic acid?

No, since salicylic acid is a beta-hydroxy acid (BHA). Niacinamide has a higher pH than acids. When combined, niacinamide raises the pH of the acid, making it less effective.

Can I mix niacinamide with retinol?

Yes, you can mix niacinamide with retinol. This combination can help to reduce the irritation caused by retinol while still enjoying its benefits. However, it is essential to note that this combination may make your skin more sensitive to the sun. Therefore, it is vital to follow up with sunscreen during the day.

Can I mix niacinamide with moisturiser?

Yes, you can mix niacinamide with moisturizer. This combination can help to improve the appearance of fine lines and wrinkles while also providing your skin with a boost of hydration.

Can I mix niacinamide with benzoyl peroxide?

Yes, you can mix niacinamide with benzoyl peroxide. This combination can help to clear up acne while also preventing future breakouts, and keeping irritation at bay.


Niacinamide is a safe and effective ingredient that can improve a variety of skin concerns. You cannot mix niacinamide with vitamin C and AHAs/BHAs, but you can mix it with hyaluronic acid, retinol, benzoyl peroxide, and similar ingredients. Be sure to follow up with sunscreen if you use niacinamide during the day.

Judy Rose

Hi, it’s Judy!

I’m a passionate skincare specialist and writer. I have more than 7 years of experience as a beauty, fashion, and lifestyle writer and editor, and I’m extremely passionate about what I do.